Formulation and Development | Sirius - The Science of Measurement

sirius-analytical.com Review:

Sirius - The Science of Measurement - Sirius Analytical are leaders in automated pKa, logP/D, solubility and dissolution measurement.

http://sirius-analytical.com/company Company | Sirius - The Science of Measurement - Sirius Analytical specialises in the provision of instruments, data and consultancy services with facilities in the US and UK.

http://sirius-analytical.com/science Overview | Sirius - The Science of Measurement - The science behind the parameters we measureWe specialise in measuring physicochemical properties of pharmaceutical and other small molecules.

http://sirius-analytical.com/science/pka pKa | Sirius - The Science of Measurement - pKa PKa values influence behaviour such absorption, binding and salt selection, as well as influencing other physicochemical properties such as lipophilicity, solubility and dissolution.

http://sirius-analytical.com/science/log-p log P | Sirius - The Science of Measurement - log PThe log P values of drugs are important because lipophilicity helps predict how drugs will move around in the body and interact with membranes.They are often used as input parameters for software that predicts pharmacokinetic properties. Other applications for log P include studies of QSAR and Environmental fate, hydrogen bonding calculations, and biopharmaceutics.

http://sirius-analytical.com/science/solubility Solubility | Sirius - The Science of Measurement - SolubilityKnowledge about the solubility of drugs is important for several reasons. It helps resolve screening and bioavailability issues during Discovery and Lead Optimization, and is valuable in planning chemistry changes and Biopharmaceutical evaluation.In Development, it’s required for biopharmaceutical classification, biowaivers and bioequivalence. It’s also required for formulation optimization and salt selection. Solubility also affects the optimization of manufacturing processes.

http://sirius-analytical.com/science/dissolution Dissolution | Sirius - The Science of Measurement - DissolutionDissolution testing has long been used in the pharmaceutical industry for optimization of formulation and quality control. Recently however, scientists are measuring dissolution rates at earlier stages of drug development and using small sample weights.The results help to understand how the API itself dissolves in aqueous media, alone or in the presence of additives and excipients, and provide valuable guidance for the development of formulations.

http://sirius-analytical.com/resource-library/overview Resource Library Overview | Sirius - The Science of Measurement - Download resources from Sirius Analytical including product brochures, application notes and webinars.

http://sirius-analytical.com/events Events | Sirius - The Science of Measurement - Latest events from Sirius Analytical, world-class providers of innovative instrumentation for chemical analysis.

http://sirius-analytical.com/email-signup Newsletter Subscription | Sirius - The Science of Measurement - Sign up to our newsletter to find out about our webinar dates, newly published scientific papers, applications, collaborations and partnerships.

http://sirius-analytical.com/analytical-services Analytical Services | Sirius - The Science of Measurement - Sirius Analytical are specialists in the provision of physicochemical data and consultancy services to the pharmaceutical industry and other business sectors.

http://sirius-analytical.com/analytical-services/screening Screening | Sirius - The Science of Measurement - Sirius Analytical screening assays are designed for larger batches of compounds and utilise our Fast UV pKa and chromatographic LogD assays. Learn more from our library application notes.

http://sirius-analytical.com/analytical-services/gold-standard-assays Gold Standard Assays | Sirius - The Science of Measurement - Sirius Analytical Gold Standard assays are definitive physchem analyses in which the analysis conditions are optimised to give the best data quality. Learn more from our library application notes.

http://sirius-analytical.com/analytical-services/formulation-and-development Formulation and Development | Sirius - The Science of Measurement - Sirius Analytical supports Formulation and Development activities through custom designed assays. Learn more from our resource library application notes.

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